5001 must be available for Alpana Designer.
This is where the previews are running.
Alpana Designer may make queries to external IP addresses (for fetching data from data sources, for example on port 1433 for SQL).
This may be detected as suspicious behavior by some security software.
For normal operation, you should let your security software allow this access to Alpana Designer.
Two processes may need to access external IP addresses :
code192.Alpana.Designer.WPF.exe : for the Data Source preview
code192.Alpana.Designer.Preview.exe : for the Widget previews